enhancing beauty through science

Restylane® Refyne

Natural Results That Refyne Your Laugh Lines. A next-generation hyaluronic acid dermal filler designed to help support your skin while keeping you looking like you.

Consultation required prior to receiving treatment.


Restylane® Refyne is designed with XpresHAn Technology™ to help soften laugh lines (nasolabial folds and marionette lines). This can help you restore a more natural look to your face while maintaining your facial expressions.1-4 So, you always look like you. Talk to your specialist and see for yourself why it’s worth it.

More Information
  • Helps soften laugh lines (nasolabial folds and marionette lines).
  • Helps restore a more youthful, natural-looking appearance, while helping you maintain your natural expressions.

What is Restylane Refyne for?

As you age, your facial skin begins to lose its elasticity and volume. As a result, your “laugh lines”, the creases that run from the sides of your nose toward the corners of your mouth, become more pronounced. Restylane Refyne injectable gel is designed to temporarily help counter this by smoothing out these wrinkles and folds and restoring a natural, soft look to your face. Restylane Refyne has been shown to maintain this effect for up to 12 months.

Note: Facial features can differ. Speak to your doctor about the lines on your face that are appropriate for treatment with Restylane Refyne.

How is Restylane Refyne used?

Restylane Refyne is injected into the facial skin through a small needle to smooth facial wrinkles and folds (laugh lines), resulting in a more youthful appearance of the skin. For most patients, the procedure only takes 15 – 30 minutes

How was Restylane Refyne Studied?

Restylane Refyne was tested to ensure that it worked properly (effective) and was safe to use, in 170 patients before it was approved for use in all patients. These patients included 160 women, 10 men, and were from various ethnic groups with multiple skin tones (pale to dark skin). Each of these patients expressed desire to improve the appearance of their facial wrinkles and folds (laugh lines).

The study was created to compare two different dermal filler gel products. It was conducted by 12 different doctors in 12 different locations across the United States.

Patients who participated in the study received an initial treatment with Restylane Refyne on one side of their face and another, similar dermal filler gel, without anesthetic, on the other side of their face. Touch-up injections were given as needed, and each patient was monitored for 12 months following the procedure to measure the effects of the treatments. For each patient, the amount of product used was based on their individual needs.

In order to objectively measure improvements in appearance over 12 months, each patient was evaluated by a doctor other than one who had performed the treatment. Patients also evaluated themselves. To measure side effects following the procedure, each patient kept a diary for 21 days to record side effects. These were then shared with the doctors.

What will Restylane Refyne do for me?

Restylane Refyne temporarily reduces signs of aging on your face by smoothing the wrinkles and folds that form around your nose and extend down to the corners of your mouth (laugh lines). This natural, smooth look should last for up to 12 months.

What side effects were seen in the clinical study?

In the study of Restylane Refyne, most patients reported the following side effects at the site where they received the injection:

  • Swelling
  • Bruising
  • Lumps/Bump Formation
  • Pain/Tenderness
  • Itching
  • Redness

Most patients said their side effects were mild, short-lived and did not require them to call their doctor. These patients said that their side effects disappeared within 1-2 weeks.

Patients also reported that the anesthetic lidocaine, which is part of the Restylane Refyne injection and used to numb the injection site, significantly reduced pain during and after their procedure.

Treatment Type Filler, Injectables
Treatment Problem or Condition Facial Volume Loss, Fine Lines, Sagging/Loose Skin, Thin Lips, Wrinkles
Size 1 cc syringe
Brand Restylane

Restylane® Refyne is for mid-to-deep injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds, in patients over the age of 21.


  • Restylane Refyne is contraindicated for patients with severe allergies manifested by a history of anaphylaxis or history or presence of multiple severe allergies.
  • Restylane Refyne may contain trace amounts of gram-positive bacterial proteins and is contraindicated for patients with a history of allergies to such material. 
  • Restylane Refyne contains lidocaine and is contraindicated for patients with a history of allergies to such material.

Restylane® Refyne is a sterile, biodegradable, viscoelastic, non-pyrogenic, clear, colorless, and homogeneous soft hyaluronic acid gel with a moderate lifting capacity. The product has a sodium hyaluronate concentration of 20 mg/mL in phosphate buffered saline at pH 7 and contains 3 mg/mL lidocaine hydrochloride.

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